craftgrn - Integrative Chromatin Accessibility and RNA Framework for Gene Regulatory Networks

Provides a reproducible framework for constructing and comparing gene regulatory networks by integrating chromatin accessibility footprint scores with matched RNA expression data. It implements context-specific enhancer-gene linking, transcription factor focused network analysis, differential network analysis, and regulatory topic modeling workflows for systematic exploration of gene regulation across conditions. Methodological background is described in Bentsen and others (2020) <doi:10.1038/s41467-020-18035-1>, Blei, Ng and Jordan (2003) <https://www.jmlr.org/papers/v3/blei03a.html>, and Chen, Li, Zhu and Chen (2015) <doi:10.48550/arXiv.1510.08628>.